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Food Reward in the Absence of Taste Receptor Signaling

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Author Topic: Food Reward in the Absence of Taste Receptor Signaling  (Read 4124 times)

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pipp3355

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Food Reward in the Absence of Taste Receptor Signaling
« on: July 06, 2008, 01:49:39 PM »

Food Reward in the Absence of Taste Receptor Signaling

Neuron, Volume 58, Issue 2, 24 April 2008, Page 295
Ivan E. de Araujo, Albino J. Oliveira-Maia, Tatyana D. Sotnikova, Raul R. Gainetdinov, Marc G. Caron, Miguel A.L. Nicolelis and Sidney A. Simon


Summary

Food palatability and hedonic value play central roles in nutrient intake. However, postingestive effects can influence food preferences independently of palatability, although the neurobiological bases of such mechanisms remain poorly understood. Of central interest is whether the same brain reward circuitry that is responsive to palatable rewards also encodes metabolic value independently of taste signaling. Here we show that trpm5−/− mice, which lack the cellular machinery required for sweet taste transduction, can develop a robust preference for sucrose solutions based solely on caloric content. Sucrose intake induced dopamine release in the ventral striatum of these sweet-blind mice, a pattern usually associated with receipt of palatable rewards. Furthermore, single neurons in this same ventral striatal region showed increased sensitivity to caloric intake even in the absence of gustatory inputs. Our findings suggest that calorie-rich nutrients can directly influence brain reward circuits that control food intake independently of palatability or functional taste transduction.

Full Article (Subscription only):

http://preview.tinyurl.com/57pgmn

There's a video about this study on YouTube:

http://ie.youtube.com/watch?v=P1O5VytOX3c
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Heidi 555

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Re: Food Reward in the Absence of Taste Receptor Signaling
« Reply #1 on: July 06, 2008, 03:29:06 PM »

Very interesting and it makes a lot of sense to me.  Even without flavor food can be satisfying and comforting.  It's interesting to imagine what we'd eat or crave without taste.  We'd probably pay more attention to the after effects of food.  I imagine how things made us feel afterwards would become more important.
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